Black Cumin Seed Oil

The following Information is gathered from my own Internet research. If you think this oil might help you and you want further info, go to... http://www.ncbi.nlm.nih.gov/pubmed/ and type in Nigella Sativa in the search bar.

Shelf life is 1-year unopened.

The chemical composition of the solvent extracted fixed oil of black cumin (Nigella sativa L.) seeds was determined by capillary GC and GC/MS. Thirty-two fatty acids (99.9%) have been identified in the fixed oil.

The major fatty acids are...

  • linoleic acid (50.2%)
  • oleic acid (19.9%)
  • margaric acid (10.3%)
  • cis-11,14-eicosadienoic acid (7.7%)
  • stearic acid (2.5%).

 

One of the earliest written references to black cumin (also called “blackseed”) is found in the book of Isaiah in the Old Testament (28:25-27).

Often called the remedy of the Prophet's after the Prophet Muhammad said:  Use this Black Seed regularly, because it is a cure for every disease, except death.”

Black seed has been in worldwide use for over 3000 years.

 

The seeds of the annual flowering plant, Nigella Sativa, have been prized for their healing properties since time immemorial.  While frequently referred to among English-speaking cultures as Roman coriander, black sesame, black cumin, black caraway and onion seed, it is known today primarily as black seed, which is at the very least an accurate description of its physical appearance. The earliest record of its cultivation and use come from ancient Egypt.

Black seed oil, in fact, was found in Egyptian pharoah Tutankhamun's tomb, dating back to approximately 3,300 years  ago.  In Arabic cultures, black cumin is known as Habbatul barakah, meaning the "seed of blessing."

On GreenMedInfo.com Black Seed (Nigella Sativa) is found to act on well over 40 health conditions that may be benefited from the use of the herb, including over 20 distinct pharmacological actions it expresses, such as:

  • Analgesic (Pain-Killing)
  • Anti-Bacterial
  • Anti-Inflammatory
  • Anti-Ulcer
  • Anti-Cholinergic
  • Anti-Fungal
  • Ant-Hypertensive
  • Antioxidant
  • Antispasmodic
  • Antiviral
  • Bronchodilator
  • Gluconeogenesis Inhibitor (Anti-Diabetic)
  • Hepatoprotective (Liver Protecting)
  • Hypotensive
  • Insulin Sensitizing
  • Interferon Inducer
  • Leukotriene Antagonist
  • Renoprotective (Kidney Protecting)
  • Tumor Necrosis Factor Alpha Inhibitor

These pharmacological actions are only a subset of a far wider number of beneficial properties intrinsic to the black seed.


The Best Way To Consume Black Cumin:

The “OIL” - is the most effective form to consume Black Cumin because the oil is more concentrated than whole seeds unpressed, and is more readily assimilated. Also, because of it’s potent, absorbable concentration – only 1 teaspoon is needed per dose. Most health experts and natural physicians recommend taking 1 teaspoon of the oil two times per day for therapeutic effects, on an empty stomach/before meals and bedtime. Or once per day, for a healthy maintenance dose or as a preventative measure.

It is best taken in the evening – unless utilizing 2x per day for therapeutic benefits. You can take the oil on its own, mixed in water or juice (*great with raw honey), or can be added to warm tea – like herbal chai, etc.

 

Modern Scientific Research on Black Cumin

Since 1959, black cumin has been examined in more than 200 different studies at universities and laboratories.

Research conducted at the Cancer Research Laboratory of Hilton Head Island in South Carolina showed that oil of black cumin fought cancerous tumors without the negative side effects chemotherapy.

The Hilton Head research showed that black cumin…

  • Increased the growth rate of bone marrow cells by a staggering 250%
  • Inhibited tumor growth by 50%
  • Stimulated immune cells and raised the interferon production (which protects cells from the destructive effect of viruses)
  • Has strongly antibacterial effects
  • Lowers the blood sugar level (essential for the treatment of diabetes)

 

 

Black cumin is especially effective for aggressive cancers whose growth depends on angiogenesis (the physiological process involving the growth of new blood vessels).

 


Black cumin seed oil inhibits cancer cell activity and can even kill some types of cancer cells. Scientific research has shown that black seed oil (Nigella sativa) is an effective treatment for cancer in animal studies, and can be as effective as anti-cancer drugs for some types of cancer. Black cumin seed oil and its extract thymoquinone have powerful benefits for various inflammatory diseases including liver cancer, melanoma skin cancer, pancreatic cancer, cervical cancer, breast cancer, bone cancer, stomach cancer, lymphoma, prostate cancer, colon cancer, and brain cancer. [1] Despite several decades of very positive research on using black seed oil against cancer, researchers have rarely advanced their work into human clinical testing, even though the benefits are strong and the risks of negative side effects are extremely small. [2]

[1] “Thymoquinone: potential cure for inflammatory disorders and cancer,” Biochem Pharmacol. 2012 Feb 15, PMID: 22005518.
[2] Department of Pharmacy, Oman Medical College, Muscat, Sultanate of Oman, “Thymoquinone in the clinical treatment of cancer: Fact or fiction?” Pharmacogn Rev. 2013 Jul;7, PMID: 24347919.


Black Seeds have been used to Treat Cancer for Thousands of Years
In two separate 2011 studies, Chinese researchers [3] and Saudi Arabian researchers [4] reviewed the scientific literature for the use of black seed oil (also called black cumin seed or Nigella sativa), with cancer. They reconfirmed the anti-cancer property of this safe and natural seed oil. They noted that black seed oil has been used as a traditional medicine for centuries. The oil and the extracted component called thymoquinone are both effective against many diseases such as cancer, cardiovascular complications, diabetes, asthma, kidney disease, etc. It is a safe and effective agent against cancer in the blood system, lungs, kidneys, liver, prostate, breast, cervix, and skin. These researchers noted that the molecular mechanisms behind its anti-cancer role are still not clearly understood. However, some studies showed that thymoquinone plays an antioxidant role and improves the body’s defense system. Black seed oil induces apoptosis, which means that it helps the body to systematically eliminate old cells, unneeded cells, and unhealthy cells (such as cancer cells) without releasing toxins into the body. It also controls the Akt pathway, which means it controls the process that manages cell survival for both normal and cancer cells. Although the anti-cancer activity of Nigella sativa was recognized thousands of years ago, it was not until the past two or three decades that modern scientific research has been undertaken to study this important traditional medicine.

[3] “Anticancer activities of Nigella sativa (black cumin),” Afr J Tradit Complement Altern Med. 2011, PMID: 22754079.
[4] “Anticancer activity of Nigella sativa (black seed) – a review,” Am J Chin Med. 2011, PMID: 22083982.


Black Seeds and Honey Work Together – Folk Medicine is Correct
Egyptian researchers studied the protective effect of bee honey and Nigella grains on the oxidative stress and the cancer that was created by exposing rats to a strong carcinogen. After the four groups of rats were exposed to the carcinogen, some groups were fed black seeds or honey, and one group was fed both black seeds and honey. The rats were evaluated after 6 months. The rats that ate black seeds received an 80% protection against oxidative stress and cancer formation. Whereas the rats that ate a daily dose of both honey and black seeds were protected 100% against oxidative stress, inflammatory responses, and cancer formation. [5]

[5] “Inhibition of methylnitrosourea (MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawely rats” J Exp Clin Cancer Res. 2002 Sep, PMID: 12385575.


Black Seed Oil is An Important Aid to Radiation Treatments
In a 2014 study, Turkish researchers reported how black seed oil could potentially be helpful to people receiving radiation treatment for cancer. They indicated that many cancer patients treated with radiation therapy suffer severe side effects during and after their treatment. This study investigated the effects of irradiation and the addition of black seed oil on the oxidant/antioxidant system in the liver tissue of irradiated rats. They exposed some of the rats to a single dose of gamma radiation. One group of rats received one gram of black seed oil per kilogram of body weight one hour before the radiation and received a daily dose afterward for 10 days. Another group received the radiation treatment and was given a saline solution instead of black seed oil. The control group was not irradiated. The analysis of the data shows that black seed oil reduces oxidative stress markers and has antioxidant effects, which also augments the antioxidant capacity in the liver tissue of rats. Thus, the use of black seed oil before radiation treatment, and for 10 days afterward, protected the rats from some of the harmful effects of radiation. [6]

[6] “Radioprotective Effects of Nigella Sativa Oil Against Oxidative Stress in Liver Tissue of Rats Exposed to Total Head Irradiation,” J Invest Surg. 2014 Mar 28, PMID: 24679182.


Radiation Protection... In a 2012 study in India, scientists investigated the effect of using an extract of black seeds on mice exposed to gamma radiation. A group of normal mice and a group of tumor bearing mice were tested. This experiment was done to mimic the human clinical setting where normal tissues of cancer patients are exposed to the harmful effects of radiation therapy. The mice were given black seed extract before being exposed to the gamma radiation. They were given 100 mg of black seed extract per 1 kg of body weight. The results showed that the extract of black seed protected the liver, spleen, brain and intestines from gamma radiation damage for both the normal mice and the mice with tumors. Researchers concluded that the liquid extract of black seeds has protective effects against radiation-induced damage and biochemical alterations. They attributed this protective effect to the ability of the extract to scavenge free radicals and to its antioxidant properties. Thus, the liquid extracted from black seeds could be used with human cancer patients who receive radiation to protect against oxidative stress in normal tissues, and to mitigate other unwanted side effects of radiation. This could improve the quality of life for cancer patients. [7]

[7] “Radioprotection by Macerated Extract of Nigella sativa in Normal Tissues of Fibrosarcoma Bearing Mice,” Indian J Pharm Sci. 2012 Sep, PMID: 23716868.


Black Seeds Interfere with Uncontrolled Cell Growth and Kill Liver Cancer Cells
In 2013, researchers in India investigated the use of thymoquinone, which is a compound derived from black seeds. Two groups of rats with liver cancer were studied. One group was given water to drink that contained 0.01% thymoquinone, and the other group was given plain water. After 16 weeks, the liver cancer nodules, liver injury markers and tumor markers were measured in both groups. The rats that did not receive the thymoquinone had substantial increases in liver tumor size. However, the rats that received 20 mg of thymoquinone per kilogram for body weight had greatly reduced liver injury markers and decreased tumor markers. The group treated with thymoquinone from black seed oil did not develop liver cancer nodules, and the amount of new tumor formation was much less than the untreated group of rats. They concluded that thymoquinone had a beneficial role in the treatment of liver cancer, because of its potent ability to prevent cancer cells from proliferating. [8]

[8] “Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma,” Toxicol Lett. 2013 Oct 23, PMID: 24012840.


A 2012 study from Egypt evaluated anti-tumor effects of bee honey and black seed oil on human liver cancer cells in laboratory experiments. They examined the antioxidant capacity of honey and black seed extract, and the ability of these substances to eliminate unhealthy cells such as cancer. They found that both honey and black seed extract were effective in reducing the viability of liver cancer cells. Honey and black seed extract also improved the antioxidant status of cells and induced cancer cell death by apoptosis. [9]

[9] “Antineoplastic effects of bee honey and Nigella sativa on hepatocellular carcinoma cells,” Integr Cancer Ther. 2012 Dec, PMID: 21147814.


Black Seed Oil Kills Lung Cancer Cells
Saudi Arabian researchers reported in 2014 that black seeds have been used in traditional medicine to treat many diseases. The antioxidant, anti-inflammatory, and antibacterial activities of black seed oil are well known. This study investigated the anti-cancer activity of black seed oil and black seed extract when used against human lung cancer cells in the laboratory. Scientists exposed lung cancer cells to black seed oil or to black seed extract for 24 hours. They used 0.01 mg/ml to 1 mg/ml of the oil or the extract in this experiment. After the exposure, the cancer cell viability was assessed.
The results showed that both the black seed oil and the black seed extract significantly reduce the population of living cancer cells and altered the cellular morphology. They found that the greater the concentration of the oil or the extract that was used to treat the cancer cells, the greater the level of cell death. Also, both the black seed oil and the black seed extract caused the cancer cells to lose their typical appearance and to appear smaller in size. Researchers concluded that their data revealed that black seed extract and black seed oil significantly reduce viability of human lung cancer cells. [10]

[10] “Cytotoxicity of Nigella sativa seed oil and extract against human lung cancer cell line,” Asian Pac J Cancer Prev. 2014, PMID: 24568529.


Black Seed Components Kill Malignant Brain Cancer Cells
Researchers from Ohio State University published a study in 2013 indicating that glioblastoma is the most aggressive and common type of malignant brain tumor in humans, with a median survival of 15 months. These researchers emphasized that there is a great need for additional therapies for the treatment of glioblastoma. Naturally occurring phytochemicals have received much scientific attention because many exhibit potent tumor killing action. Thymoquinone is one of the bioactive compounds of black seed oil. Thymoquinone has anti-oxidant, anti-inflammatory and anti-cancer actions. It has selective cytotoxic properties for human cells, which means that it kills human cancer cells while not being harmful to normal cells.
This specific study examined how thymoquinone selectively inhibits the ability of glioblastoma cancer cells of the brain and spinal cord from making clones of themselves. Thymoquinone, however, does not inhibit normal cell activity in the human brain and spinal cord. Another important ability of thymoquinone is the inhibition of autophagy genes in cancer cells. Autophagy in cancer cells enables continued growth of tumor cells by maintaining cellular energy production. If autophagy is inhibited, then cellular energy production for cancer cells will also be inhibited. This will result in a regression of tumor activity, and will extend the survival of organs affected by tumors. Thus, thymoquinone’s ability to inhibit cancer cells from making clones of themselves and its ability to inhibit cancer cells from reusing cellular materials from other cells by means of autophagy, provide an exciting and emerging strategy for cancer therapy. [11]

[11] “Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells,” PLoS One. 2013 Sep 9, PMID: 24039814.


Black Seeds Inhibit Breast Cancer
A 2013 study, conducted in Malaysia, addressed the anti-cancer efficiency of thymoquinone when it was used for long-term treatment of human breast cancer cell lines in the laboratory.Thymoquinone showed a sustained ability to inhibit breast cancer cell proliferation with long-term treatment. The length of inhibition was determined by the size of the thymoquinone dose. Larger doses produced greater inhibition.

[12] “Cellular responses with thymoquinone treatment in human breast cancer cell line MCF-7,” Pharmacognosy Res. 2013 Jul, PMID: 23900121.


Black Seeds Kill Leukemia Cells
Malaysian researchers noted in a 2013 study that there is a growing interest in the use of naturally occurring compounds from traditional medicine which have anti-cancer potential. Nigella sativa (black seed) is one of the most widely studied plants. This annual herb grows in countries bordering the Mediterranean Sea and India. Thymoquinone is one active ingredient isolated from Nigella sativa. The anti-cancer effect of thymoquinone, via the induction of apoptosis resulting from mitochondrial dysfunction, was assessed in an acute leukemia cell line. Researchers found that treatment of leukemia cells with thymoquinone encouraged apoptosis resulting in cell death. These results indicate that thymoquinone from black seeds could be a promising agent for the treatment of leukemia.

[13] “Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro,” Molecules. 2013 Sep 12, PMID: 24036512.


Black Seed Oil Inhibits and Kills Colon Cancer Cells
Researchers from the University of Mississippi Medical Center stated in their 2007 study that that the chemotherapy drug 5-fluorouracil continues to be the chemotherapeutic gold-standard for the treatment of colon cancer. However, they noted that the side effects of 5-FU are numerous due to its ability to attack both healthy and cancerous cells. They responded to previous research findings showing that antioxidants have an ability to deter certain disease processes, especially cancer. They studied epigallocatechin-3-gallate, the most abundant catechin found in green tea, and thymoquinone which is considered to be the most important anti-cancer component of black seeds. Black seeds are known for their powerful scavenger abilities. They are an inhibitor of oxidative stress, and have been utilized in the Middle East for centuries because of their capability to heal many different diseases. The objective of this study was to investigate the role of sustained delivery of thymoquinone from black seeds, catechin from green tea, and the chemotherapy drug 5-FU on the metabolic activity and the structural changes in human colon cancer cells in laboratory cultures. Results of this study showed that green tea catechin and black seed thymoquinone produced significant cancer cell destruction and interfered with cellular metabolic functions, which was comparable to cells exposed to sustained drug delivery of the chemotherapy drug 5-FU. Morphologically, cellular changes occurred after exposure to green tea catechin and thymoquinone  for 24 hours, which was comparable to the cellular changes seen in cells exposed to the chemotherapy drug 5-FU. Ultimately, the researchers concluded that the natural agents may offer a safe alternative treatment for colon cancer.

[14] “A comparison of 5-fluorouracil and natural chemotherapeutic agents, EGCG and thymoquinone, delivered by sustained drug delivery on colon cancer cells,” Biomed Sci Instrum., 2007, PMID: 17487093.


Black Seeds Useful for Helicobacter pylori Infection
In 2010, Saudi Arabian researchers indicated that a large number of diseases are ascribed to Helicobacter pylori (H. pylori), particularly chronic active gastritis, peptic ulcer disease and gastric cancer. Successful treatment of H. pylori infection with antimicrobial agents can lead to regression of H. pylori-associated disorders. H. pylori resistance against antibiotics is increasing, and it is necessary to find new effective agents. Nigella sativa seed (black seeds), a commonly used herb, possesses anti-helicobacter activity. The present study was undertaken to evaluate the efficacy of black seeds for the eradication of H. pylori infection in 88 human non-ulcer dyspeptic patients. Patients were randomly assigned to four groups. The groups received various combinations of clarithromycin and/or amoxicillin (antibiotics), omeprazole (anti gastric reflex drug), and black seed oil. Researchers found that black seeds possess clinically useful anti-H. pylori activity, comparable to the combined use of all three drugs that were tested. [16]

[16] “Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia,” Saudi J Gastroenterol. 2010 Jul-Sep, PMID: 20616418.


Combining Thymoquinone from Black Seeds with Conventional Cancer Treatments

In 2011, German researchers described the drug doxorubicin as being a mainstay of cancer chemotherapy despite its cardiotoxicity and its limited ability to treat multi-drug resistant cancers. Recent studies revealed a protective effect of thymoquinone, a non-toxic constituent of the essential oil of Nigella sativa, against doxorubicin-induced cardiotoxicity. In summary, they found that thymoquinone is a booster for the anti-cancer effect of the chemotherapy agent doxorubicin in certain cancer cell lines. [17]

[17] “Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin,” Cancer Chemother Pharmacol. 2011 April, PMID: 20582416.


In 2013, researchers from Singapore reported that there are a limited number of therapeutic agents for cancer, and cancer cells are developing resistance to these agents. Thus, there is a need to discover novel agents to treat breast cancer. The antitumor activities of thymoquinone, a compound isolated from black seed oil, were used to treat mice with breast cancer.Thymoquinone treatment was found to suppress tumor growth, and this effect was further enhanced by combining it with the chemotherapy drug doxorubicin. [18]

[18] “Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS,” PLoS One. 2013 October 2, PMID: 24098377.

[19] “Review on molecular and therapeutic potential of thymoquinone in cancer,” Nutr Cancer, 2010, PMID: 20924969.
[20] “Thymoquinone in the clinical treatment of cancer: Fact or fiction?” Pharmacogn Rev. 2013 July, PMID: 24347919.


Conclusion
After reviewing over 120 scientific research abstracts on the use of black seed oil and thymoquinone with various types of cancers, I began to wonder why there have been so few clinical trials with cancer patients. I couldn’t stop asking myself, “If black seed oil possesses the significant anti-cancer properties that have been shown by all this research, and it has been proven to not be toxic to healthy human cells, then why are scientists still doing laboratory research? Why are human trials not being undertaken yet?” The history of black seed use is well known. Traditional folk medicine has been safely using black seeds since the time of the Egyptian Pharaohs. Black seed oil was found in the tomb of the Egyptian Pharaoh Tutankhamen, which indicates that the oil probably had an important role in ancient Egyptian practices. [21] Archeologists also found black seeds mixed with honey and bee’s wax in a pilgrim flask from the Old Hittite Period level of Boyalı Höyük (Mound), dating from around 1650 BC, in north-central Turkey. [22] Black seeds and black seed oil have been used for dozens of diseases with great success ever since that time throughout a large portion of the world. Yet, when it comes to cancer treatment, this remedy is still stuck in the laboratory as if it were a dangerous unproven toxic substance. Let’s remember black seeds and black seed oil are food! They are completely edible. They have been used for flavoring food and have been used as daily tonics and remedies for thousands of years. We do not need more test tube research or animal studies to prove that black seeds are safe and effective in laboratory experiments. The research that we need involves the development of protocols for using black seed oil in a clinical setting with cancer patients. It is clear from the research that black seed oil and thymoquinone are both effective against cancer and do not have harmful side effects. It’s time for clinical trials.

[21] “Black Seed: Seed of Blessing,”  By The Institute of Tibb Medicine, Johannesburg, South Africa, Published in Awareness Magazine, September/October 2000.http://www.awarenessmag.com/sepoct0/SO0_BLACK_SEED.HTM
[22] “Ancient nigella seeds from Boyalı Höyük in north-central Turkey,” Journal of Ethnopharmacology, Volume 124, Issue 3, 30 July 2009, Pages 416–420, PMID: 19505557.


Why is Clinical Research on Black Seed Oil as a Treatment for Cancer so Rare?
The answer to this question may easily involve the controlling power of pharmaceutical companies. As some of the researchers noted in their abstracts, conventional chemotherapy drugs are becoming less effective. Some of the studies cited above investigated the use of black seed oil and thymoquinone in combination with existing chemotherapy drugs. When they did these types of experiments, they often found that the combination worked better than chemotherapy drugs by themselves. In some experiments, thymoquinone worked equally as well as chemotherapy drugs, which might mean that toxic chemotherapy agents just might be able to be replaced by a natural seed extract, which has no harmful effects. For people with cancer, this could be great news, but to the pharmaceutical industry, this would be extremely bad news for profitability.


See Also:    Black Seed – ‘The Remedy For Everything But Death’


 

 

 

 

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