Isopropyl Myristate (IPM)
Isopropyl Myristate (IPM) is very commonly used in food and cosmetics.
HUMAN EXPOSURE STUDIES/ /In a/ repeated Patch-test 1.28-1.70 g isopropyl myristate was applied for 24 hr every other day for 15 applications to 50 health volunteers. In each case a 48 hr challenge application was given 3 wk later. The study has failed to detect any sensitizing potential. [European Commission, ESIS; IUCLID Dataset,Isopropyl Myristate (110-27-0) p.35 (2000 CD-ROM edition). Available from, as of May 12, 2010: http://esis.jrc.ec.europa.eu/ **PEER REVIEWED**
HUMAN EXPOSURE STUDIES/ Four separate human sensitization studies testing an aerosol antiperspirant concentrate containing 52-58% isopropyl myristate produced no reactions indicative of sensitization in a total of 320 subjects.
Isopropyl myristate 50% in cyclomethicone solution (Full Marks Solution - SSL International) is a new fluid treatment with a physical mode of action that uses a 10-minute contact time /for treatment of head lice.
No safety or allergy issues found.
Isopropyl Myristate (IPM) was consistently found to be the far superior transdermal carrier for transport of all types of drugs studied.
The carrier effect is multiplied when the drugs to be carried were prepared in a microemulsion.