How Marijuana Suppositories Can Save Lives
This is a common reaction to the suggestion that cannabis can be used as a suppository. Rectal administrations (suppositories) have an unfairly bad reputation in North America, despite the diverse benefits they offer. This article aims to educate about the advantages associated with the rectal application of cannabis and provide a simple set of guidelines for the effective use of suppositories.
There are many advantages to the rectal administration of cannabis not afforded by other routes. Medicine may still be administered even if the oral route is impaired (e.g., due to vomiting, an injured jaw or throat, or gastrointestinal difficulties) or disallowed due to the oral intake restrictions that are frequently required both before and after surgery.
Avoiding the gastrointestinal tract (normal digestion) also prevents first-pass metabolism by the stomach and liver, which break down molecules into their constituent parts (including Δ9-tetrahydrocannabinol, otherwise known as THC).
Suppository application skips around the normal digestion process and allows the whole active constituents in the Cannabis to reach the bloodstream in much higher concentrations.
In the case of THC, the liver transforms around half of what is ingested into the significantly more psychoactive metabolite 11-Hydroxy-Δ9-tetrahydrocannabinol. (In non sciFi language: the liver makes raw cannabis MORE psychoactive which means you get higher)
Rectal administration not only avoids these effects, but also allows a much greater proportion of THC to eventually reach the blood stream. This increase in overall efficiency is also shown in the different levels of bioavailability that different administration routes afford, as seen in Fig. 1. Rectal administration also allows for medicine to exert effects over localized ailments (e.g., hemorrhoidal tissue, inflammation of the rectum, or tumors in the rectal cavity). This form of use also has a much faster uptake than oral administration (around 10 minutes, on average) and leads to more consistent blood concentrations of the active constituents. The speed and reliability of their uptake combined with their circumvention of many of the issues surrounding both ingestion and inhalation make rectal applications an excellent addition to both new and pre-existing therapeutic regimens.
Bioavailability = how much of the medicine actually makes it into your bloodstream.
Rectal dehydration can drastically reduce the effectiveness of suppositories. Staying well hydrated by maintaining a healthy consumption of both water and electrolytes should prevent this in most cases, but specific medical conditions may cause it as well, in which case the solution may not be as simple. As always, if there are concerns, a medical professional should be consulted.
Anyone who decides to take advantage of the benefits provided by suppositories should do so with a good understanding of the process involved. Although not overly complex, the few simple instructions outlined below will enable their effective use.
The following instructions have been adapted for use with Natures Meds CANCER BLEND liquid Oil products.
Nicholas Fraleigh writes for Cannabis Digest.
Vaginal Suppository application... is equally as effective as Anal with the added benefit of making your vagina "very happy!" This is the equivalent to a very concentrated version of our Cannagasm product. Pure, Raw Cannabis Concentrates should be avoided here as they create a very painful stinging. Our Cancer Blend product is diluted in Black Seed and Chia oils which are harmless in the vagina and no stinging or other negative side effects have been reported from this use.